By J.M. Parry, C.F. Arlett
This selection of sixty nine papers investigates 'in vitro' metabolic activation arrangements for 2 particular pairs of chemical analogues, benzidine (BZD) with 4,4-diaminoterphenyl (DAT) and 4-dimethyl-aminoazobenzene (DAB) with 4-cyanodimethylaniline (CDA). The arrangements chosen have been uninduced rat liver (using rats of an identical pressure because the bioassay). Aroclor-induced rat liver, uninduced mouse liver (using an identical mouse pressure as utilized in the 'in vivo' cytogenetics assays), and uninduced bird. the key bulk of the assays defined within the examine concerned using huge universal batches of those fifty nine arrangements. The examine used to be subsidized by means of the uk Environmental Mutagen Society (UKEMS) and will stand as a major landmark in genetic toxicology.
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This choice of sixty nine papers investigates 'in vitro' metabolic activation arrangements for 2 particular pairs of chemical analogues, benzidine (BZD) with 4,4-diaminoterphenyl (DAT) and 4-dimethyl-aminoazobenzene (DAB) with 4-cyanodimethylaniline (CDA). The arrangements chosen have been uninduced rat liver (using rats of an analogous pressure because the bioassay).
Extra info for Comparative Genetic Toxicology: The Second UKEMS Collaborative Study
Values less than twice that of the solvent control) in all three replicate experiments. 42 Bacterial Mutation (Core Study) DISCUSSION These negative responses are not unexpected since even with more suitable conditions it is not always possible to show a mutagenic response with DAB. g. Lefevre and Ashby (1981) found that in the· presence of Aroclorinduced rat liver S9 mix a preincubation period was necessary in order to detect DAB as a mutagen in the Salmonella typhimurium assay and that the co-mutagen, norharman, could be used to produce an enhanced positive response.
Mutat. Res. F. and Liskens. F. (1980). DNA repair in pollen: range of mutagens inducing repair, effect of replication inhibitors and changes in thymidine nucleotide metabolism during repair. Mol. Gen. Genet. M. J. (1981). Genetic activity of 42 coded compounds in the mitotic gene conversion assay using Saccharomyces cerevisiae, strain D4. Progr. Mutat. Res. 1: 456-467 Jenssen, D. and Ramel, C. (1980). The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 43 agents tested.
Even though a concentration of 10000 pg/plate was incorporated without any detectable toxicity to any of the tester strains, a significant dose-response was found only in the much lower and narrower dose range of 1-100 pg/plate. 47 Mutagenicity of BZD, DAT, DAB and CDA in Bacteria 60'r------------------------------------------------------, "CD "'< Ill 40 t .... a: Ill 1&1 > 1&1 a: 20 100 0~-----------------------------------------------------J 0 25 so DOSE
Comparative Genetic Toxicology: The Second UKEMS Collaborative Study by J.M. Parry, C.F. Arlett